Authors: Thomas Girke, Tyler Backman, Dan Evans
Last update: 25 May, 2016
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This vignette is part of the NIA funded Longevity Genomics project. For more information on this project please visit its
website here. The GitHub repository of the corresponding R package
is available here and the most recent version of this
vignette can be found here.
The data package
longevityDrugs contains molecular structures and annotation information
of longevity-associated drugs (LADs). An iterative process will be used to assemble, update and
curate this data set long-term (Backman et al., 2011; Cao et al., 2008). Most small molecules will be identified by integrating several
large-scale community data sources such as data from drug databases (e.g.
Drugbank), bioassay databases (e.g. PubChem Bioassay, ChEMBL), literature,
drug-related gene expression fingerprints (e.g. LINCS), genetic (e.g. GWAS) and
phenotype resources. This will also include nearest neighbors of LADs sharing
with them structural, physicochemical or biological properties.