longevityDrugs - Database of Longevity-Associated Drugs (LAD)

Authors: Thomas Girke, Tyler Backman, Dan Evans

Last update: 25 May, 2016

Alternative formats of this vignette: Single-page .Rmd HTML, .Rmd, .R

Introduction

This vignette is part of the NIA funded Longevity Genomics project. For more information on this project please visit its website here. The GitHub repository of the corresponding R package is available here and the most recent version of this vignette can be found here.

The data package longevityDrugs contains molecular structures and annotation information of longevity-associated drugs (LADs). An iterative process will be used to assemble, update and curate this data set long-term (Backman et al., 2011; Cao et al., 2008). Most small molecules will be identified by integrating several large-scale community data sources such as data from drug databases (e.g. Drugbank), bioassay databases (e.g. PubChem Bioassay, ChEMBL), literature, drug-related gene expression fingerprints (e.g. LINCS), genetic (e.g. GWAS) and phenotype resources. This will also include nearest neighbors of LADs sharing with them structural, physicochemical or biological properties.