1. Install R for your operating system from CRAN.

  2. Install RStudio from RStudio.

  3. Install CRAN Packages from R console like this:

install.packages(c("pkg1", "pkg2")) 
install.packages("pkg.zip", repos=NULL)
  1. Install Bioconductor packages as follows:
source("http://www.bioconductor.org/biocLite.R")
library(BiocInstaller)
BiocVersion()
biocLite()
biocLite(c("pkg1", "pkg2"))
  1. For more details consult the Bioc Install page and BiocInstaller package.